Voile, there you have it, a great urine Spray bottle ... To keep your dog away from certain areas in your home and maintain your friendship, try making a natural dog deterrent. Homemade Dog Deterrent By Bibiana da Silva Things You'll Need. Shake the bottle to mix the cayenne throughout the water. of cayenne powder. Lastly, shake well to incorporate the ingredients. Step 1 Pour 1 cup of water into the spray bottle and add 2 tbsp. 5.